Mouse Anti-PARD6B Recombinant Antibody (1C4) (CBMAB-P0775-YC)

Name: Mouse Anti-PARD6B Recombinant Antibody (1C4)
SKU: CBMAB-P0775-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C4

Application

ELISA, IF, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

par-6 partitioning defective 6 homolog beta (C. elegans)

Introduction

PARD6B is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.

Entrez Gene ID

84612

UniProt ID

Q9BYG5

Alternative Names

Par-6 Family Cell Polarity Regulator Beta; PAR-6 Beta; PAR6B; Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta; Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans); Par-6 Partitioning Defective 6 Homolog Beta; Partitioning Defective 6 Homolog Beta; PAR-6B;

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Biological Process

AxonogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Cell divisionIEA:UniProtKB-KW
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Centrosome cycleManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of cellular localizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell membrane
Cell junction, tight junction

Zhang, M., Jiang, L., Liu, X. Y., Liu, F. X., Zhang, H., Zhang, Y. J., ... & Yu, H. (2024). KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network. Heliyon, 10(1), e24287.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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