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Mouse Anti-PARD6B Recombinant Antibody (1C4) (CBMAB-P0775-YC)

Provided herein is a Mouse monoclonal antibody against Human Par-6 Family Cell Polarity Regulator Beta. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all PARD6B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C4
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
par-6 partitioning defective 6 homolog beta (C. elegans)
Introduction
PARD6B is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
Entrez Gene ID
84612
UniProt ID
Q9BYG5
Alternative Names
Par-6 Family Cell Polarity Regulator Beta; PAR-6 Beta; PAR6B; Par-6 (Partitioning Defective 6, C.Elegans) Homolog Beta; Par-6 Partitioning Defective 6 Homolog Beta (C. Elegans); Par-6 Partitioning Defective 6 Homolog Beta; Partitioning Defective 6 Homolog Beta; PAR-6B;
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Biological Process
AxonogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Cell divisionIEA:UniProtKB-KW
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Centrosome cycleManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of cellular localizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cell membrane
Cell junction, tight junction
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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