PARD6B

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq]

Full Name

par-6 partitioning defective 6 homolog beta (C. elegans)

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Biological Process

AxonogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Cell divisionIEA:UniProtKB-KW
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Centrosome cycleManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of cellular localizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell membrane
Cell junction, tight junction