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Mouse Anti-PARL Recombinant Antibody (CBT4436) (V2LY-0625-LY2214)


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Tested Data
Mouse Anti-PARL Recombinant Antibody (CBT4436) (V2LY-0625-LY2214) in WB
Mouse Anti-PARL Recombinant Antibody (CBT4436) (V2LY-0625-LY2214) in WB

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4436
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Presenilin Associated Rhomboid Like
Entrez Gene ID
55486
UniProt ID
Q9H300
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity).
Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088).
Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872).
Biological Process
Membrane protein proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrial fusionIEA:Ensembl
Negative regulation of intrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of release of cytochrome c from mitochondriaIEA:Ensembl
ProteolysisManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagy of mitochondrionIEA:Ensembl
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Regulation of proteolysisManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Signal peptide processingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion inner membrane
P-beta
Nucleus
Translocated into the nucleus by an unknown mechanism (PubMed:17116872).
Topology
Mitochondrial matrix: 53-101
Helical: 102-121
Mitochondrial intermembrane: 122-167
Helical: 168-187
Mitochondrial matrix: 188-207
Helical: 208-230
Mitochondrial intermembrane: 231-244
Helical: 245-262
Mitochondrial matrix: 263-272
Helical: 273-289
Mitochondrial intermembrane: 290-295
Helical: 296-318
Mitochondrial matrix: 319-332
Helical: 333-354
Mitochondrial intermembrane: 355-379
PTM
P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.
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For research use only. Not intended for any clinical use.

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