Mouse Anti-PARL Recombinant Antibody (CBT4436) (V2LY-0625-LY2214)


Basic Information
Application | Note |
WB | 1:500-1:2,000 |
ELISA | 1:10,000 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088).
Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872).
Mitochondrial fusionIEA:Ensembl
Negative regulation of intrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of release of cytochrome c from mitochondriaIEA:Ensembl
ProteolysisManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagy of mitochondrionIEA:Ensembl
Regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Regulation of proteolysisManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Signal peptide processingManual Assertion Based On ExperimentIBA:GO_Central
P-beta
Nucleus
Translocated into the nucleus by an unknown mechanism (PubMed:17116872).
Helical: 102-121
Mitochondrial intermembrane: 122-167
Helical: 168-187
Mitochondrial matrix: 188-207
Helical: 208-230
Mitochondrial intermembrane: 231-244
Helical: 245-262
Mitochondrial matrix: 263-272
Helical: 273-289
Mitochondrial intermembrane: 290-295
Helical: 296-318
Mitochondrial matrix: 319-332
Helical: 333-354
Mitochondrial intermembrane: 355-379
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Related Products
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Mouse Anti-PARL Recombinant Antibody (F-3) (CAT#: CBMAB-P0792-YC)
Mouse Anti-PARL Recombinant Antibody (8C4B2) (CAT#: CBMAB-P0791-YC)
Mouse Anti-PARL Recombinant Antibody (4F4) (CAT#: CBMAB-P0790-YC)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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