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Rabbit Anti-PASK Recombinant Antibody (C70B2) (CBMAB-P0843-YC)

Provided herein is a Rabbit monoclonal antibody against Human PAS Domain Containing Serine/Threonine Kinase. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PASK antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
C70B2
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PAS Domain Containing Serine/Threonine Kinase
Introduction
PASK is a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes.
Entrez Gene ID
Human23178
Mouse269224
Rat301617
UniProt ID
HumanQ96RG2
MouseQ8CEE6
RatQ5PQT0
Alternative Names
PAS Domain Containing Serine/Threonine Kinase; PASKIN; PAS Domain-Containing Serine/Threonine-Protein Kinase; Per-Arnt-Sim (PAS) Domain Kinase; EC 2.7.11.1; PAS-Kinase; KIAA0135; STK37; HPASK;
Function
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Biological Process
Energy homeostasisISS:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of glycogen biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of translationManual Assertion Based On ExperimentTAS:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glucagon secretionISS:UniProtKB
Regulation of respiratory gaseous exchangeISS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
PTM
Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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