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Mouse Anti-PAX5 Antibody (1B1) (CBMAB-0782-YC)

Provided herein are mouse monoclonal antibodies against Human PAX5. The antibody clone 1B1 can be used for immunoassay techniques, such as IP and MA.
See all PAX5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B1
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Paired Box 5
Introduction
PAX5 (paired box 5) is a member of the paired box (PAX) family of transcription factors. PAX5 is the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. The deregulation of transcription of PAX5 gene contributes to the pathogenesis of these lymphomas.
Entrez Gene ID
5079
UniProt ID
Q02548
Alternative Names
ALL3; BSAP
Function
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361).
Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361).
In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238).
Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238).
(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781).
Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172).
Biological Process
Adult behaviorIEA:Ensembl
AgingIEA:Ensembl
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cerebral cortex developmentIEA:Ensembl
Embryonic cranial skeleton morphogenesisIEA:Ensembl
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Lateral ventricle developmentIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of histone H3-K9 methylationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal muscle cell differentiationIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Leukemia, acute lymphoblastic, 3 (ALL3):
A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.
PTM
O-glycosylated.
Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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