Mouse Anti-PAX7 Recombinant Antibody (1G11) (CBMAB-A6347-LY)

Name: Mouse Anti-PAX7 Recombinant Antibody (1G11)
SKU: CBMAB-A6347-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1G11

Application

WB, ELISA

Immunogen

PAX7 (NP_002575.1, 411 a.a. ~ 520 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human, Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Pax7

Introduction

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Entrez Gene ID

Human	5081
Mouse	18509

UniProt ID

Human	P23759
Mouse	P47239

Alternative Names

HUP1; PAX7B

Function

Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.

Biological Process

Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ developmentIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Rhabdomyosarcoma 2 (RMS2):
A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Myopathy, congenital, progressive, with scoliosis (MYOSCO):
An autosomal recessive muscular disorder characterized by infantile onset of progressive muscular atrophy, hypotonia, ptosis, scoliosis and dysmorphic facial features. Disease severity is variable, ranging from mild to severe.

Manceau, L., Richard Albert, J., Lollini, P. L., Greenberg, M. V., Gilardi-Hebenstreit, P., & Ribes, V. (2022). Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs. PLoS Genetics, 18(5), e1009782.

Nord, H., Kahsay, A., Dennhag, N., Pedrosa Domellöf, F., & von Hofsten, J. (2022). Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation. Developmental Dynamics, 251(9), 1423-1438.

Choi, J. H., Han, D. H., & Gong, S. P. (2021). Cloning and characterization of a cDNA encoding a paired box protein, PAX7, from black sea bream, Acanthopagrus schlegelii. Journal of Animal Reproduction and Biotechnology, 36(4), 314-322.

Wang, M., Song, W., Jin, C., Huang, K., Yu, Q., Qi, J., ... & He, Y. (2021). Pax3 and pax7 exhibit distinct and overlapping functions in marking muscle satellite cells and muscle repair in a marine teleost, sebastes schlegelii. International Journal of Molecular Sciences, 22(7), 3769.

Park, H. J., Lee, W. Y., Lee, R., Park, J. K., Hong, K. H., Park, C., & Song, H. (2020). Expression of paired box protein PAX7 in prepubertal boar testicular gonocytes. Acta Histochemica, 122(6), 151595.

Al Tanoury, Z., Rao, J., Tassy, O., Gobert, B., Gapon, S., Garnier, J. M., ... & Pourquié, O. (2020). Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro. Development, 147(12), dev187344.

Feichtinger, R. G., Mucha, B. E., Hengel, H., Orfi, Z., Makowski, C., Dort, J., ... & Dumont, N. A. (2019). Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genetics in Medicine, 21(11), 2521-2531.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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