PAX7

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
Pax7
Function
Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ developmentIEA:UniProtKB-KW
Negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Rhabdomyosarcoma 2 (RMS2):
A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Myopathy, congenital, progressive, with scoliosis (MYOSCO):
An autosomal recessive muscular disorder characterized by infantile onset of progressive muscular atrophy, hypotonia, ptosis, scoliosis and dysmorphic facial features. Disease severity is variable, ranging from mild to severe.
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Anti-PAX7 antibodies

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Mouse Anti-PAX7 Antibody (PAX7) (CBMAB-0889-YC)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken, Amphibian, Avian, Cattle, Dog, Fish, Goat, Human, Mouse, Sheep, Pig, Rat, Turtle, Frog, Zebrafish
Clone: PAX7
Application*: CI, F, FP, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (4F8) (CBMAB-A6353-LY)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4F8
Application*: WB, E
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (3C9) (CBMAB-A6349-LY)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C9
Application*: WB, E
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (2B9) (CBMAB-A6348-LY)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 2B9
Application*: WB, E
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (1G11) (CBMAB-A6347-LY)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 1G11
Application*: WB, E
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (PAX7/497) (CBMAB-P0893-YC)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Chicken, Zebrafish
Clone: PAX7/497
Application*: WB, F, E, IC, IF, C
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (PAX7/1187) (CBMAB-P0892-YC)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: PAX7/1187
Application*: P
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (6290C1a) (CBMAB-P0890-YC)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6290C1a
Application*: DB, WB
Datasheet SDS

Mouse Anti-PAX7 Recombinant Antibody (1E12) (CBMAB-P0889-YC)

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Target: PAX7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 1E12
Application*: E, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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