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Mouse Anti-PCDH10 Recombinant Antibody (2H6) (CBMAB-P0960-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H6
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PCDH10 (NP_065866, 18-127 aa) partial recombinant protein with GST tag. Immunogen sequence: SQLHYTVQEE QEHGTFVGNI AEDLGLDITK LSARGFQTVP NSRTPYLDLN LETGVLYVNE KIDREQICKQ SPSCVLHLEV FLENPLELFQ VEIEVLDIND NPPSFPEPDL
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 18-127

Target

Full Name
protocadherin 10
Introduction
PCDH10 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration.
Entrez Gene ID
57575
UniProt ID
Q9P2E7
Alternative Names
Protocadherin 10; Protocadherin-10; KIAA1400; OL-PCDH; PCDH19;
Function
Potential calcium-dependent cell-adhesion protein.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 19-715
Helical: 716-736
Cytoplasmic: 737-1040
More Infomation

Zhen, Y., Pavez, M., & Li, X. (2023). The role of Pcdh10 in neurological disease and cancer. Journal of Cancer Research and Clinical Oncology, 149(10), 8153-8164.

Zhang, N., Gao, X., Yuan, Q., Fu, X., Wang, P., Cai, F., ... & Deng, J. (2023). E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1. Clinical Epigenetics, 15(1), 77.

Yang, J., Hou, C., Wang, H., Perez, E. A., Do-Umehara, H. C., Dong, H., ... & Liu, J. (2023). Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10. Cancer Letters, 555, 216025.

Ferri, S. L., Dow, H. C., Schoch, H., Lee, J. Y., Brodkin, E. S., & Abel, T. (2021). Age-and sex-specific fear conditioning deficits in mice lacking Pcdh10, an autism associated gene. Neurobiology of learning and memory, 178, 107364.

Jao, T. M., Fang, W. H., Ciou, S. C., Yu, S. L., Hung, Y. L., Weng, W. T., ... & Yang, Y. C. (2021). PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer. Cancer letters, 499, 290-300.

Zhou, J., Wang, L., Sun, Q., Chen, R., Zhang, C., Yang, P., ... & Sun, Y. (2021). Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR‐576‐5p/PCDH10 axis. Clinical and translational medicine, 11(11), e565.

Seo, S. I., Yoon, J. H., Byun, H. J., & Lee, S. K. (2021). HOTAIR induces methylation of PCDH10, a tumor suppressor gene, by regulating DNMT1 and sponging with miR-148b in gastric adenocarcinoma. Yonsei medical journal, 62(2), 118.

Shi, B., Mao, S., Xu, L., Li, Y., Sun, X., Liu, Z., ... & Qiu, Y. (2020). Quantitation analysis of PCDH10 methylation in adolescent idiopathic scoliosis using pyrosequencing study. Spine, 45(7), E373-E378.

Curia, M. C., Fantini, F., Lattanzio, R., Tavano, F., Di Mola, F., Piantelli, M., ... & Cama, A. (2019). High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma. BMC cancer, 19, 1-11.

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For research use only. Not intended for any clinical use.

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