Mouse Anti-Pcf11 Recombinant Antibody (C-9) (CBMAB-P1038-YC)

Name: Mouse Anti-Pcf11 Recombinant Antibody (C-9)
SKU: CBMAB-P1038-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

C-9

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)

Introduction

Pcf11 binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage.

Entrez Gene ID

Human	51585
Mouse	74737
Rat	361605

UniProt ID

Human	O94913
Mouse	Q3TT32
Rat	D3ZY40

Alternative Names

PCF11 Cleavage And Polyadenylation Factor Subunit; PCF11, Cleavage And Polyadenylation Factor II Subunit, Homolog (S. Cerevisiae); PCF11, Cleavage And Polyadenylation Factor Subunit, Homolog (S. Cerevisiae); Pre-MRNA Cleavage Complex II Protein Pcf11; KIAA0824;

Function

Component of pre-mRNA cleavage complex II.

Biological Process

mRNA cleavage1 PublicationNAS:UniProtKB
mRNA polyadenylationManual Assertion Based On ExperimentIBA:GO_Central
Termination of RNA polymerase II transcriptionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Szewc, L., Zhang, X., Bajczyk, M., Bielewicz, D., Zimna, M., Yura, K., ... & Tsuge, T. (2024). Plant Cleavage Factor I complex is essential for precise cleavage and polyadenylation site determination. bioRxiv, 2024-03.

Ait Said, M., Bejjani, F., Abdouni, A., Ségéral, E., & Emiliani, S. (2023). Premature transcription termination complex proteins PCF11 and WDR82 silence HIV-1 expression in latently infected cells. Proceedings of the National Academy of Sciences, 120(49), e2313356120.

Kamieniarz-Gdula, K., Gdula, M. R., Panser, K., Nojima, T., Monks, J., Wiśniewski, J. R., ... & Proudfoot, N. J. (2019). Selective roles of vertebrate PCF11 in premature and full-length transcript termination. Molecular cell, 74(1), 158-172.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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