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Mouse Anti-PCGF6 Antibody (V2-5046) (CBMAB-0794-YC)

Provided herein are mouse monoclonal antibodies against Human PCGF6. The antibody clone 1A2 can be used for immunoassay techniques, such as IP.
See all PCGF6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-5046
Antibody Isotype
IgG2b
Application
IP

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PCGF6
Introduction
PcG proteins are known to form protein complexes and function as transcription repressors. PCGF6 (polycomb group ring finger 6) contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PCGF6 has been shown to interact with some PcG proteins and act as a transcription repressor and is found to be regulated by cell cycle dependent phosphorylation.
Entrez Gene ID
84108
UniProt ID
Q9BYE7
Alternative Names
MBLR; RNF134
Function
Transcriptional repressor (PubMed:12167161).
May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162).
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Biological Process
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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