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Mouse Anti-PCGF6 Recombinant Antibody (2B8) (CBMAB-P1045-YC)

Provided herein is a Mouse monoclonal antibody against Human Polycomb Group Ring Finger 6. The antibody can be used for immunoassay techniques, such as ELISA.
See all PCGF6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B8
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa225-325 from human PCGF6 (NP_001011663) with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 225-325

Target

Full Name
PCGF6
Introduction
PCGF6 contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation.
Entrez Gene ID
84108
UniProt ID
Q9BYE7
Alternative Names
Polycomb Group Ring Finger 6; Ring Finger Protein 134; RNF134; MBLR; Mel18 And Bmi1-Like RING Finger Protein; Polycomb Group RING Finger Protein 6; Mel18 And Bmi1-Like RING Finger; RING Finger Protein 134;
Function
Transcriptional repressor (PubMed:12167161).
May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162).
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Biological Process
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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