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Mouse Anti-PCLO Recombinant Antibody (4G3.3) (CBMAB-P1058-YC)

Provided herein is a Mouse monoclonal antibody against Mouse Piccolo Presynaptic Cytomatrix Protein. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all PCLO antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
4G3.3
Antibody Isotype
IgG, κ
Application
WB, IHC-P

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Piccolo Presynaptic Cytomatrix Protein
Introduction
PCLO is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder.
Entrez Gene ID
Mouse26875
Rat56768
UniProt ID
MouseQ9QYX7
RatQ9JKS6
Alternative Names
Piccolo Presynaptic Cytomatrix Protein; Aczonin; ACZ; Piccolo (Presynaptic Cytomatrix Protein); Protein Piccolo; KIAA0559; PCH3;
Function
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity).
After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity).
At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity).
Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity).
Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity).
Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).
Biological Process
Cytoskeleton organizationISS:UniProtKB
Insulin secretionIEA:Ensembl
Presynapse to nucleus signaling pathwayIEA:Ensembl
Presynaptic active zone assemblyManual Assertion Based On ExperimentIBA:GO_Central
Protein localization to synapseManual Assertion Based On ExperimentIBA:GO_Central
Regulation of exocytosisIEA:Ensembl
Synaptic vesicle clusteringIEA:Ensembl
Synaptic vesicle exocytosis1 PublicationNAS:UniProtKB
Cellular Location
Cell junction, synapse, presynaptic active zone
Colocalizes with BSN in developing axons.
Involvement in disease
Pontocerebellar hypoplasia 3 (PCH3):
A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum. Brain MRI shows an abnormally small cerebellum and brainstem, decreased cerebral white matter, and a thin corpus callosum. PCH3 features include seizures, short stature, optic atrophy, progressive microcephaly, severe developmental delay.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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