Sign in or Register   Sign in or Register
  |  

Mouse Anti-PCNT Recombinant Antibody (CBYC-P222) (CBMAB-P1083-YC)

Provided herein is a Mouse monoclonal antibody against Human Pericentrin. The antibody can be used for immunoassay techniques, such as FC, ICC, IF.
See all PCNT antibodies

Summary

Host Animal
Mouse
Specificity
Human, Hamster
Clone
CBYC-P222
Antibody Isotype
IgG1
Application
FC, ICC, IF

Basic Information

Specificity
Human, Hamster
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pericentrin
Introduction
PCNT binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II.
Entrez Gene ID
Human5116
Hamster101833326
UniProt ID
HumanO95613
HamsterA0A3Q0CSV1
Alternative Names
AW476095; C86676; KEN; Pcnt2; kendrin; m239Asp; m275Asp
Function
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
Biological Process
Cilium assemblyManual Assertion Based On ExperimentIDA:MGI
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionIEA:InterPro
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
Involvement in disease
Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2):
Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence.
PTM
Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation (PubMed:22722493, PubMed:25503564).
The C-terminal fragment is rapidly degraded following cleavage (PubMed:22722493).
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-PCNT Recombinant Antibody (CBYC-P222)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare