Mouse Anti-PCOLCE Recombinant Antibody (18) (CBMAB-P1085-YC)

Name: Mouse Anti-PCOLCE Recombinant Antibody (18)
SKU: CBMAB-P1085-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Procollagen C-Endopeptidase Enhancer

Introduction

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino-and carboxyl-terminal peptide extensions known as N-and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.

Entrez Gene ID

5118

UniProt ID

Q15113

Alternative Names

Procollagen C-Endopeptidase Enhancer; Procollagen C-Proteinase Enhancer 1; Procollagen, Type 1, COOH-Terminal Proteinase Enhancer; Type I Procollagen COOH-Terminal Proteinase Enhancer; Type 1 Procollagen C-Proteinase Enhancer Protein; Procollagen COOH-Terminal Proteinase Enhancer 1;

Function

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.

Biological Process

Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

PTM

C-terminally processed at multiple positions.

Yao, X., Wang, B., Su, Y., Bing, Z., Li, Q., Dong, Q., ... & Yuan, G. (2024). SOX9 Promotes Collagen VI Secretion by Upregulating PCOLCE in Neurofibroma. Molecular Neurobiology, 1-15.

Guo, Q., Gao, X., Li, J., Liu, Y., Liu, J., Yang, H., ... & Ma, X. (2023). High expression of PCOLCE gene indicate poor prognosis in patients and are associated with immune infiltration in glioma. Scientific Reports, 13(1), 3820.

Gao, H., & Li, Q. (2022). A pan-cancer analysis of the oncogenic role of procollagen C-endopeptidase enhancer (PCOLCE) in human. Medicine, 101(52), e32444.

Xiang, A., Lin, X., Xu, L., Chen, H., Guo, J., & Zhou, F. (2020). PCOLCE is potent prognostic biomarker and associates with immune infiltration in gastric cancer. Frontiers in Molecular Biosciences, 7, 544895.

Wang, S., Zhong, L., Li, Y., Xiao, D., Zhang, R., Liao, D., ... & Kang, T. (2019). Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma. Theranostics, 9(15), 4342.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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