PCOLCE
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino-and carboxyl-terminal peptide extensions known as N-and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.
Full Name
Procollagen C-Endopeptidase Enhancer
Function
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
Biological Process
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
PTM
C-terminally processed at multiple positions.
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Anti-PCOLCE antibodies
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Target: PCOLCE
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P223
Application*: E, IC, WB
Target: PCOLCE
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 261730
Application*: IP, WB
Target: PCOLCE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 18
Application*: E
Target: PCOLCE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L782
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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