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PCOLCE

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino-and carboxyl-terminal peptide extensions known as N-and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.

Full Name

Procollagen C-Endopeptidase Enhancer

Function

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.

Biological Process

Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

PTM

C-terminally processed at multiple positions.

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Anti-PCOLCE antibodies

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Mouse Anti-PCOLCE Recombinant Antibody (CBYC-P223) (CBMAB-P1089-YC)

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Target: PCOLCE

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P223

Application*: E, IC, WB

Rat Anti-PCOLCE Recombinant Antibody (261730) (CBMAB-P1086-YC)

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Target: PCOLCE

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: 261730

Application*: IP, WB

Mouse Anti-PCOLCE Recombinant Antibody (18) (CBMAB-P1085-YC)

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Target: PCOLCE

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 18

Application*: E

Rat Anti-PCOLCE Recombinant Antibody (14L782) (CBMAB-P1084-YC)

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Target: PCOLCE

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 14L782

Application*: WB

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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