Mouse Anti-PCP4 Recombinant Antibody (1E3) (CBMAB-P1091-YC)

Name: Mouse Anti-PCP4 Recombinant Antibody (1E3)
SKU: CBMAB-P1091-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1E3

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

PCP4 (NP_006189.2, 1-62 aa) partial recombinant protein with GST tag. Immunogen sequence: MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS QS

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-62

Target

Full Name

Purkinje cell protein 4

Introduction

PCP4 has biased expression in prostate (RPKM 108.8), urinary bladder (RPKM 73.3) and 6 other tissues.

Entrez Gene ID

5121

UniProt ID

P48539

Alternative Names

Purkinje Cell Protein 4; Brain-Specific Polypeptide PEP-19; Calmodulin Regulator Protein PCP4; Brain Specific Polypeptide PEP19; Brain-Specific Antigen PCP-4; PEP-19; PEP19;

Function

Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793).
For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429).

Biological Process

Calmodulin dependent kinase signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron differentiationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

cytoplasm
cytosol
nucleus
protein-containing complex

More Infomation

References

Hu, D., Dong, X., Wang, Q., Liu, M., Luo, S., Meng, Z., ... & Song, W. (2023). PCP4 Promotes Alzheimer’s Disease Pathogenesis by Affecting Amyloid-β Protein Precursor Processing. Journal of Alzheimer's Disease, (Preprint), 1-14.

Kitazono, I., Hamada, T., Yoshimura, T., Kirishima, M., Yokoyama, S., Akahane, T., & Tanimoto, A. (2020). PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells. Laboratory Investigation, 100(12), 1551-1563.

He, L., Lee, G. T., Zhou, H., Buhimschi, I. A., Buhimschi, C. S., Weiner, C. P., & Mason, C. W. (2019). Expression, regulation, and function of the calmodulin accessory protein PCP4/PEP-19 in myometrium. Reproductive Sciences, 26(12), 1650-1660.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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