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Mouse Anti-PCSK1N Recombinant Antibody (1E9) (CBMAB-P1094-YC)

Provided herein is a Mouse monoclonal antibody against Human Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor. The antibody can be used for immunoassay techniques, such as ELISA, IF, IHC-P, WB.
See all PCSK1N antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E9
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
PCSK1N (NP_037403.1, 173-260 aa) partial recombinant protein with GST tag. Immunogen sequence: DGPAGPDAEE AGDETPDVDP ELLRYLLGRI LAGSADSEGV AAPRRLRRAA DHDVGSELPP EGVLGALLRV KRLETPAPQV PARRLLPP
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 173-260

Target

Full Name
proprotein convertase subtilisin/kexin type 1 inhibitor
Introduction
PCSK1N functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity.
Entrez Gene ID
27344
UniProt ID
Q9UHG2
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor; Proprotein Convertase 1 Inhibitor; Pro-SAAS; Granin-Like Neuroendocrine Peptide; PROSAAS; BigLEN;
Function
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).
Big LEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
PEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
Biological Process
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Peptide hormone processingIEA:Ensembl
Response to coldIEA:Ensembl
Response to dietary excessIEA:Ensembl
Cellular Location
Secreted
Golgi apparatus, trans-Golgi network
A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).
PTM
Proteolytically cleaved in the Golgi.
O-glycosylated with a core 1 or possibly core 8 glycan.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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