Mouse Anti-PCSK1N Recombinant Antibody (1E9) (CBMAB-P1094-YC)

Name: Mouse Anti-PCSK1N Recombinant Antibody (1E9)
SKU: CBMAB-P1094-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E9

Application

ELISA, IF, IHC-P, WB

Immunogen

PCSK1N (NP_037403.1, 173-260 aa) partial recombinant protein with GST tag. Immunogen sequence: DGPAGPDAEE AGDETPDVDP ELLRYLLGRI LAGSADSEGV AAPRRLRRAA DHDVGSELPP EGVLGALLRV KRLETPAPQV PARRLLPP

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 173-260

More Infomation

Target

Full Name

proprotein convertase subtilisin/kexin type 1 inhibitor

Introduction

PCSK1N functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity.

Entrez Gene ID

27344

UniProt ID

Q9UHG2

Alternative Names

Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor; Proprotein Convertase 1 Inhibitor; Pro-SAAS; Granin-Like Neuroendocrine Peptide; PROSAAS; BigLEN;

Function

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).
Big LEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
PEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.

Biological Process

Neuropeptide signaling pathwayIEA:UniProtKB-KW
Peptide hormone processingIEA:Ensembl
Response to coldIEA:Ensembl
Response to dietary excessIEA:Ensembl

Cellular Location

Secreted
Golgi apparatus, trans-Golgi network
A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).

PTM

Proteolytically cleaved in the Golgi.
O-glycosylated with a core 1 or possibly core 8 glycan.

Liu, Z., Tian, M., Jia, Y., Guo, Y., Zhao, X., Meng, N., ... & Fu, R. (2023). LncRNA PCSK1N-202 regulates CD34+ hematopoietic cells proliferation in MDS patients via PIM2/HIF-1alpha.

Zheng, X., Kumar, M., Konkalmatt, P., Asico, L., Jose, P. A., & Armando, I. (2020). Role of PCSK1N and GPR83 in salt resistance. The FASEB Journal, 34(S1), 1-1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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