Human PCSK1N ELISA Kit (V2LY-0626-LY5072)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.052 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
27.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
proprotein convertase subtilisin/kexin type 1 inhibitor
Function
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).
Big LEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
PEN
Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
Biological Process
Neuropeptide signaling pathwayIEA:UniProtKB-KW
Peptide hormone processingIEA:Ensembl
Response to coldIEA:Ensembl
Response to dietary excessIEA:Ensembl
Cellular Location
Secreted
Golgi apparatus, trans-Golgi network
A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).
PTM
Proteolytically cleaved in the Golgi.
O-glycosylated with a core 1 or possibly core 8 glycan.

Liu, Z., Tian, M., Jia, Y., Guo, Y., Zhao, X., Meng, N., ... & Fu, R. (2023). LncRNA PCSK1N-202 regulates CD34+ hematopoietic cells proliferation in MDS patients via PIM2/HIF-1alpha.

Zheng, X., Kumar, M., Konkalmatt, P., Asico, L., Jose, P. A., & Armando, I. (2020). Role of PCSK1N and GPR83 in salt resistance. The FASEB Journal, 34(S1), 1-1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Pcsk1n ELISA Kit (CAT#: V2LY-0626-LY2904)

Related Products

Mouse Pcsk1n ELISA Kit (CAT#: V2LY-0626-LY2904)

Mouse Anti-PCSK1N Recombinant Antibody (1E9) (CAT#: CBMAB-P1094-YC)

Isotype control

For research use only. Not intended for any clinical use.

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