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Mouse Anti-PCSK7 Recombinant Antibody (1B8) (CBMAB-P1102-YC)

Provided herein is a Mouse monoclonal antibody against Human Proprotein Convertase Subtilisin/Kexin Type 7. The antibody can be used for immunoassay techniques, such as FC, ICC, IF.
See all PCSK7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B8
Antibody Isotype
IgG2a
Application
FC, ICC, IF

Basic Information

Immunogen
Full length human recombinant protein of human PCSK7 (NP_004707) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proprotein Convertase Subtilisin/Kexin Type 7
Introduction
PCSK7 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart.
Entrez Gene ID
9159
UniProt ID
Q16549
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 7; Subtilisin/Kexin-Like Protease PC7; Lymphoma Proprotein Convertase; Prohormone Convertase 7; Proprotein Convertase 7; Proprotein Convertase 8; Spc7; LPC; PC7; PC8;
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Biological Process
Peptide hormone processing1 PublicationNAS:UniProtKB
Protein processingManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Golgi apparatus, trans-Golgi network membrane
Seems to be localized intracellularly to the trans Golgi network.
Topology
Extracellular: 142-667
Helical: 668-688
Cytoplasmic: 689-785
PTM
Cysteine residues in the cytoplasmic tail are probably palmitoylated.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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