PCSK7

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

Full Name

Proprotein Convertase Subtilisin/Kexin Type 7

Function

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Biological Process

Peptide hormone processing1 PublicationNAS:UniProtKB
Protein processingManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Golgi apparatus, trans-Golgi network membrane
Seems to be localized intracellularly to the trans Golgi network.

Topology

Extracellular: 142-667
Helical: 668-688
Cytoplasmic: 689-785

PTM

Cysteine residues in the cytoplasmic tail are probably palmitoylated.
N-glycosylated.