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Rat Anti-PDC Recombinant Antibody (120G8) (CBMAB-P1124-YC)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
120G8
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.2% BSA, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
decarboxylase
Introduction
PDC is a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II.
Entrez Gene ID
20028
UniProt ID
Q9QW08
Alternative Names
Phosducin; 33 KDa Phototransducing Protein; PHD; Phosducin-Like Orphan Protein; G Beta Gamma Binding Protein; Protein MEKA; PhLOP; MEKA; PhLP;
Function
May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
PhototransductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytosol
Nucleus
Cell projection, cilium, photoreceptor outer segment
Photoreceptor inner segment
Isoform 2
Nucleus
PTM
Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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