PDC

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

Full Name

decarboxylase

Function

May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
PhototransductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Visual perceptionIEA:UniProtKB-KW

Cellular Location

Cytoplasm, cytosol
Nucleus
Cell projection, cilium, photoreceptor outer segment
Photoreceptor inner segment
Isoform 2
Nucleus

PTM

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.