PDC

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
Full Name
decarboxylase
Function
May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
PhototransductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytosol
Nucleus
Cell projection, cilium, photoreceptor outer segment
Photoreceptor inner segment
Isoform 2
Nucleus
PTM
Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
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Anti-PDC antibodies

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Rat Anti-PDC Recombinant Antibody (120G8) (CBMAB-P1124-YC)

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Target: PDC
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 120G8
Application*: F
Datasheet SDS

Mouse Anti-PDC Recombinant Antibody (E-1) (CBMAB-P1125-YC)

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Target: PDC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: E-1
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-PDC Recombinant Antibody (11E314) (CBMAB-P1123-YC)

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Target: PDC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 11E314
Application*: F, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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