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Rabbit Anti-PDCD4 Recombinant Antibody (D29C6) (CBMAB-P1160-YC)

Provided herein is a Rabbit monoclonal antibody against Human Programmed Cell Death 4. The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P, IF.
See all PDCD4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D29C6
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Programmed Cell Death 4
Introduction
PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding.
Entrez Gene ID
Human27250
Mouse18569
Rat64031
Monkey695345
UniProt ID
HumanQ53EL6
MouseQ61823
RatQ9JID1
MonkeyG7N146
Alternative Names
Programmed Cell Death 4; Programmed Cell Death 4 (Neoplastic Transformation Inhibitor); Neoplastic Transformation Inhibitor Protein; Nuclear Antigen H731; Protein 197/15a; H731; Programmed Cell Death Protein 4; Nuclear Antigen H731-Like;
Function
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
BMP signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cell agingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideISS:BHF-UCL
Epithelial to mesenchymal transition involved in cardiac fibroblast developmentISS:BHF-UCL
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell cycle1 PublicationNAS:UniProtKB
Negative regulation of cytokine production involved in inflammatory responseISS:BHF-UCL
Negative regulation of JUN kinase activityISS:UniProtKB
Negative regulation of myofibroblast differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular associated smooth muscle cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of vascular associated smooth muscle cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of inflammatory responseISS:BHF-UCL
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular associated smooth muscle cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Nucleus
Cytoplasm
Shuttles between the nucleus and cytoplasm (By similarity).
Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133).
PTM
Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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