PDCD4

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Full Name

Programmed Cell Death 4

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
BMP signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cell agingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideISS:BHF-UCL
Epithelial to mesenchymal transition involved in cardiac fibroblast developmentISS:BHF-UCL
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell cycle1 PublicationNAS:UniProtKB
Negative regulation of cytokine production involved in inflammatory responseISS:BHF-UCL
Negative regulation of JUN kinase activityISS:UniProtKB
Negative regulation of myofibroblast differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular associated smooth muscle cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of vascular associated smooth muscle cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of inflammatory responseISS:BHF-UCL
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular associated smooth muscle cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Nucleus
Cytoplasm
Shuttles between the nucleus and cytoplasm (By similarity).
Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133).

PTM

Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.