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Mouse Anti-PDCL Recombinant Antibody (4G5) (CBMAB-P1176-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosducin-like
Introduction
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.
Entrez Gene ID
5082
UniProt ID
Q13371
Alternative Names
Phosducin Like; PhLP; Phosducin-Like Protein; PHLOP1; PhLP1;
Function
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Isoform 1
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
Isoform 2
Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Biological Process
Cell projection organizationIEA:UniProtKB-KW
Heterotrimeric G-protein complex assemblyIEA:Ensembl
Positive regulation of smoothened signaling pathwayISS:UniProtKB
Regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Signal transduction1 PublicationNAS:UniProtKB
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Cell projection, cilium
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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