PDCL

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq]

Full Name

phosducin-like

Function

Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Isoform 1
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
Isoform 2
Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Biological Process

Cell projection organizationIEA:UniProtKB-KW
Heterotrimeric G-protein complex assemblyIEA:Ensembl
Positive regulation of smoothened signaling pathwayISS:UniProtKB
Regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Signal transduction1 PublicationNAS:UniProtKB
Visual perceptionIEA:UniProtKB-KW

Cellular Location

Cell projection, cilium