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Mouse Anti-PDE10A Recombinant Antibody (1B2) (CBMAB-P1182-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 10A. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all PDE10A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B2
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 10A
Introduction
PDE10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Entrez Gene ID
10846
UniProt ID
Q9Y233
Alternative Names
Phosphodiesterase 10A; CAMP And CAMP-Inhibited CGMP 3,5-Cyclic Phosphodiesterase 10A; DJ416F21.1 (Phosphodiesterase 10A); Phosphodiesterase 10A1 (PDE10A1); Phosphodiesterase 10A7 (PDE10A7); 3,5 CAMP/CGMP Phosphodiesterase; EC 3.1.4.17; EC 3.1.4.35;
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:27058447, PubMed:17389385).
Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:27058447, PubMed:17389385).
May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447).
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Dyskinesia, limb and orofacial, infantile-onset (IOLOD):
An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2 (ADSD2):
An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
PTM
Isoform PDE10A2
Phosphorylated on Thr-16.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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