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Mouse Anti-PDE10A Recombinant Antibody (4E1) (CBMAB-A6514-LY)

The product is antibody recognizes PDE10A. The antibody 4E1 immunoassay techniques such as: sELISA, ELISA.
See all PDE10A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E1
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
PDE10A (NP_006652, 242 a.a. ~ 333 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphodiesterase 10A
Introduction
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate (Fujishige et al., 2000 [PubMed 10998054]).[supplied by OMIM
Entrez Gene ID
10846
UniProt ID
Q9Y233
Alternative Names
FLJ11894; FLJ25677; HSPDE10A
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:27058447, PubMed:17389385).
Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:27058447, PubMed:17389385).
May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447).
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
cGMP catabolic processIEA:UniProtKB-UniPathway
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Dyskinesia, limb and orofacial, infantile-onset (IOLOD):
An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2 (ADSD2):
An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
PTM
Isoform PDE10A2
Phosphorylated on Thr-16.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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