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Mouse Anti-PDE3A Recombinant Antibody (2D7) (CBMAB-P1202-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 3A. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all PDE3A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PDE3A (NP_000912, 533-640 aa) partial recombinant protein with GST tag. Immunogen sequence: TPASSLVSKI SAVQFPESAD TTAKQSLGSH RALTYTQSAP DLSPQILTPP VICSSCGRPY SQGNPADEPL ERSGVATRTP SRTDDTAQVT SDYETNNNSD SSDIVQNE
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 533-640

Target

Full Name
phosphodiesterase 3A, cGMP-inhibited
Introduction
PDE3A is a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure.
Entrez Gene ID
5139
UniProt ID
Q14432
Alternative Names
Phosphodiesterase 3A; Cyclic GMP-Inhibited Phosphodiesterase A; Phosphodiesterase 3A, CGMP-Inhibited; EC 3.1.4.17; CGI-PDE A; CAMP Phosphodiesterase, Myocardial CGMP-Inhibited;
Function
Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:8695850, PubMed:8155697, PubMed:25961942).
Has also activity toward cUMP (PubMed:27975297).
Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099).
Biological Process
cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to cGMPManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayTAS:Reactome
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Oocyte maturationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of oocyte developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of meiotic nuclear divisionIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cytoplasm, cytosol
Involvement in disease
Hypertension and brachydactyly syndrome (HTNB):
A syndrome characterized by brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, and altered baroreflex blood pressure regulation. It results in death from stroke before age 50 years when untreated. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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