Human Recombinant PDE3A, Active protein, GST Tag (V2LY-0526-LY6031)
Compare
Online Inquiry
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Has also activity toward cUMP (PubMed:27975297).
Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099).
Cellular response to cGMPManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayTAS:Reactome
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cAMP-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Oocyte maturationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of oocyte developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of vascular permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of meiotic nuclear divisionIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cytoplasm, cytosol
A syndrome characterized by brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, and altered baroreflex blood pressure regulation. It results in death from stroke before age 50 years when untreated. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals.
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon
$30 eGift Card
Submit a review
Loading...
Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
Online InquiryContact us
