Mouse Anti-PDE6D Recombinant Antibody (4H6) (CBMAB-P1224-YC)

Name: Mouse Anti-PDE6D Recombinant Antibody (4H6)
SKU: CBMAB-P1224-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4H6

Application

ELISA, IF, WB

Immunogen

PDE6D (AAH07831, 1-150 aa) full length recombinant protein with GST tag. Immunogen sequence: MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-150

More Infomation

Target

Full Name

phosphodiesterase 6D, cGMP-specific, rod, delta

Introduction

PDE6D is the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants.

Entrez Gene ID

5147

UniProt ID

O43924

Alternative Names

Phosphodiesterase 6D; Phosphodiesterase 6D, CGMP-Specific, Rod, Delta; GMP-PDE Delta; Protein P17; PDED; Retinal Rod Rhodopsin-Sensitive CGMP 3,5-Cyclic Phosphodiesterase Subunit Delta; JBTS22;

Function

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853).
Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361).
Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846).
Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity).
Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

Biological Process

Response to stimulusIEA:UniProtKB-KW
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm, cytosol
Cytoplasmic vesicle membrane
Cytoplasm, cytoskeleton, cilium basal body

Involvement in disease

Joubert syndrome 22 (JBTS22):
A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PDE6D Recombinant Antibody (5C7) (CAT#: CBMAB-P1225-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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