Human Recombinant PDE6D protein, GST Tag (V2LY-0526-LY6041)

Name: Human Recombinant PDE6D protein, GST Tag
SKU: V2LY-0526-LY6041
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PDE6D protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 43 kDa.

Molecule Mass

43 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

phosphodiesterase 6D, cGMP-specific, rod, delta

Function

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853).
Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361).
Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846).
Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity).
Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

Biological Process

Response to stimulusIEA:UniProtKB-KW
Visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm, cytosol
Cytoplasmic vesicle membrane
Cytoplasm, cytoskeleton, cilium basal body

Involvement in disease

Joubert syndrome 22 (JBTS22):
A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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