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Mouse Anti-PDE8A Recombinant Antibody (1H6) (CBMAB-P1230-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 8A. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PDE8A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PDE8A (NP_002596.1, 32-121 aa) partial recombinant protein with GST tag. Immunogen sequence: RLPQGQKTAA LPRTRGAGLL ESELRDGSGK KVAVADVQFG PMRFHQDQLQ VLLVFTKEDN QCNGFCRACE KAGFKCTVTK EAQAVLACFL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 32-121

Target

Full Name
phosphodiesterase 8A
Introduction
PDE8A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes.
Entrez Gene ID
5151
UniProt ID
O60658
Alternative Names
Phosphodiesterase 8A; High Affinity CAMP-Specific And IBMX-Insensitive 3,5-Cyclic Phosphodiesterase 8A; CAMP-Specific Cyclic Nucleotide Phosphodiesterase 8A; EC 3.1.4.17; EC 3.1.4.53; HsT19550;
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167).
May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).
Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299).
Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of hydrogen peroxide-induced cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
extracellular exosome
PTM
Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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