PDE8A

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000). See MIM 171885.[supplied by OMIM

Full Name

phosphodiesterase 8A

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167).
May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).
Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299).
Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).

Biological Process

cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of hydrogen peroxide-induced cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol
extracellular exosome

PTM

Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.