Mouse Anti-PDGFB Recombinant Antibody (108128) (CBMAB-P1245-YC)

Platelet Derived Growth Factor Subunit B

PDGFB is a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor.

Platelet Derived Growth Factor Subunit B; Becaplermin; Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog); Platelet-Derived Growth Factor Beta Polypeptide; Platelet-Derived Growth Factor B Chain; Proto-Oncogene C-Sis; PDGF Subunit B; PDGF-2; PDGF2; SIS;

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395).
Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

Activation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:UniProtKB
Cell chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to growth factor stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to mycophenolic acidISS:UniProtKB
Cellular response to platelet-derived growth factor stimulusISS:BHF-UCL
Embryonic placenta developmentISS:UniProtKB
Heart developmentISS:UniProtKB
Interleukin-18-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Metanephric glomerular mesangial cell developmentISS:UniProtKB
Monocyte chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of platelet activationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of vascular associated smooth muscle cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Paracrine signalingISS:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of calcium ion importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell-substrate adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glomerular filtrationISS:UniProtKB
Positive regulation of glomerular mesangial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of hyaluronan biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of metanephric mesenchymal cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of vascular associated smooth muscle cell dedifferentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of vascular associated smooth muscle cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of vascular associated smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Protein kinase C signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Reactive oxygen species metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Response to woundingManual Assertion Based On ExperimentIDA:BHF-UCL

Secreted
Released by platelets upon wounding.

Basal ganglia calcification, idiopathic, 5 (IBGC5):
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.