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Mouse Anti-PDK2 Recombinant Antibody (CBT4545) (V2LY-0625-LY151)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4545
Antibody Isotype
IgG2b
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human PDK2 (AA: 178-404) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
pyruvate dehydrogenase kinase, isozyme 2
Entrez Gene ID
5164
UniProt ID
Q15119
Function
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
Biological Process
Cellular response to nutrientISS:UniProtKB
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Glucose homeostasisISS:UniProtKB
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Insulin receptor signaling pathwayISS:UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of acetyl-CoA biosynthetic process from pyruvateISS:UniProtKB
Regulation of calcium-mediated signalingIEA:Ensembl
Regulation of cellular ketone metabolic processISS:UniProtKB
Regulation of gluconeogenesisISS:UniProtKB
Regulation of glucose metabolic processISS:UniProtKB
Regulation of pHISS:UniProtKB
Cellular Location
Mitochondrion matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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