PDK2

PDK2 is a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes.

pyruvate dehydrogenase kinase, isozyme 2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Cellular response to nutrientISS:UniProtKB
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Glucose homeostasisISS:UniProtKB
Glucose metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Insulin receptor signaling pathwayISS:UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of acetyl-CoA biosynthetic process from pyruvateISS:UniProtKB
Regulation of calcium-mediated signalingIEA:Ensembl
Regulation of cellular ketone metabolic processISS:UniProtKB
Regulation of gluconeogenesisISS:UniProtKB
Regulation of glucose metabolic processISS:UniProtKB
Regulation of pHISS:UniProtKB

Mitochondrion matrix