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Mouse Anti-PDLIM2 Recombinant Antibody (CBFYM-3053) (CBMAB-M3249-FY)

This product is mouse antibody that recognizes PDLIM2. The antibody CBFYM-3053 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all PDLIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3053
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDZ And LIM Domain 2
Introduction
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
64236
UniProt ID
Q96JY6
Alternative Names
PDZ And LIM Domain 2; Mystique; PDZ And LIM Domain Protein 2; PDZ-LIM Protein Mystique; SLIM
Function
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
May be partially nuclear.
Isoform 1
Cytoplasm, cytoskeleton
Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Isoform 2
Cytoplasm, cytoskeleton
Isoform 3
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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