PDLIM2

PDLIM2 is a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia.
Full Name
PDZ And LIM Domain 2
Function
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
May be partially nuclear.
Isoform 1
Cytoplasm, cytoskeleton
Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Isoform 2
Cytoplasm, cytoskeleton
Isoform 3
Nucleus
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Anti-PDLIM2 antibodies

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Mouse Anti-PDLIM2 Recombinant Antibody (15C1) (CBMAB-P1333-YC)

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Target: PDLIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15C1
Application*: F, WB
Datasheet SDS

Mouse Anti-PDLIM2 Recombinant Antibody (14D9) (CBMAB-P1332-YC)

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Target: PDLIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14D9
Application*: IH, F, WB
Datasheet SDS

Mouse Anti-PDLIM2 Recombinant Antibody (11A12) (CBMAB-P1331-YC)

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Target: PDLIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11A12
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-PDLIM2 Recombinant Antibody (10C4) (CBMAB-P1330-YC)

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Target: PDLIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 10C4
Application*: WB, P, IC, IF
Datasheet SDS

Mouse Anti-PDLIM2 Recombinant Antibody (CBFYM-3053) (CBMAB-M3249-FY)

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Target: PDLIM2
Host: Mouse
Specificity: Human
Clone: CBFYM-3053
Application*: WB, IP, IF, E
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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