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Mouse Anti-PDLIM5 Recombinant Antibody (1H10) (CBMAB-P1336-YC)

Provided herein is a Mouse monoclonal antibody against Human PDZ And LIM Domain 5. The antibody can be used for immunoassay techniques, such as WB, FC.
See all PDLIM5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H10
Antibody Isotype
IgG2a
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human PDLIM5(NP_006448) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDZ and LIM domain 5
Introduction
PDLIM5 is a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses.
Entrez Gene ID
10611
UniProt ID
Q96HC4
Alternative Names
PDZ And LIM Domain 5; Enigma-Like PDZ And LIM Domains Protein; Enigma Homolog; ENH; Enigma-Like LIM Domain Protein; PDZ And LIM Domain Protein 5; Enh1; LIM; L9;
Function
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Cell growth involved in cardiac muscle cell developmentISS:BHF-UCL
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of dendritic spine morphogenesisISS:UniProtKB
Regulation of synapse assemblyISS:UniProtKB
Cellular Location
Cell junction, synapse, postsynaptic density
Cell junction, synapse, presynapse
Cell junction, synapse, postsynapse
Cytoplasm, cytosol
Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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