PDLIM5

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized. [provided by RefSeq]

Full Name

PDZ and LIM domain 5

Function

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).

Biological Process

Actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Cell growth involved in cardiac muscle cell developmentISS:BHF-UCL
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Muscle structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of dendritic spine morphogenesisISS:UniProtKB
Regulation of synapse assemblyISS:UniProtKB

Cellular Location

Cell junction, synapse, postsynaptic density
Cell junction, synapse, presynapse
Cell junction, synapse, postsynapse
Cytoplasm, cytosol
Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.