Sign in or Register   Sign in or Register
  |  

Mouse Anti-PDYN Recombinant Antibody (NOC.1) (CBMAB-D2160-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Prodynorphin (PDYN). The antibody can be used for immunoassay techniques, such as IHC, IHC-Fr, RIA.
See all PDYN antibodies

Summary

Host Animal
Mouse
Specificity
Human, Pig
Clone
NOC.1
Antibody Isotype
IgG
Application
IHC, IHC-Fr, RIA

Basic Information

Immunogen
Synthetic peptide corresponding to part of the native molecule conjugated to Bovine Serum Albumin
Specificity
Human, Pig
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
prodynorphin
Introduction
PDYN is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine.
Entrez Gene ID
Human5173
Pig445529
UniProt ID
HumanP01213
PigP01214
Alternative Names
Prodynorphin; Neoendorphin-Dynorphin-Enkephalin Prepropeptide; Beta-Neoendorphin-Dynorphin; Preproenkephalin B; Preprodynorphin; Leu-Enkephalin; Leumorphin; Rimorphin;
Function
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
Biological Process
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Sensory perceptionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Spinocerebellar ataxia 23 (SCA23):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
PTM
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PDYN Recombinant Antibody (NOC.1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare