Mouse Anti-PDZD8 Recombinant Antibody (4E3) (CBMAB-P1390-YC)

Name: Mouse Anti-PDZD8 Recombinant Antibody (4E3)
SKU: CBMAB-P1390-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

4E3

Application

ELISA, WB

Immunogen

PDZD8 (NP_776152, 949-1059 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PDZ domain containing 8

Introduction

PDZD8 has broad expression in bone marrow (RPKM 51.5), testis (RPKM 17.7) and 24 other tissues.

Entrez Gene ID

118987

UniProt ID

Q8NEN9

Alternative Names

PDZ Domain Containing 8; Sarcoma Antigen NY-SAR-84/NY-SAR-104; PDZK8; PDZ Domain-Containing Protein 8;

Function

Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544).
PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca2+ transfer (PubMed:29097544).
In neurons, involved in the regulation of dendritic Ca2+ dynamics by regulating mitochondrial Ca2+ uptake in neurons (PubMed:29097544).
Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987).
May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Lipid transportIEA:UniProtKB-KW
Mitochondrial calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion-endoplasmic reticulum membrane tetheringManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum membrane
Localizes at mitochondria-endoplasmic reticulum contact sites.

Topology

Helical: 2-24

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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