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Mouse Anti-PDZD8 Recombinant Antibody (4E3) (CBMAB-P1390-YC)

Provided herein is a Mouse monoclonal antibody against Human PDZ Domain Containing 8. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PDZD8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E3
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PDZD8 (NP_776152, 949-1059 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDZ domain containing 8
Introduction
PDZD8 has broad expression in bone marrow (RPKM 51.5), testis (RPKM 17.7) and 24 other tissues.
Entrez Gene ID
118987
UniProt ID
Q8NEN9
Alternative Names
PDZ Domain Containing 8; Sarcoma Antigen NY-SAR-84/NY-SAR-104; PDZK8; PDZ Domain-Containing Protein 8;
Function
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544).
PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca2+ transfer (PubMed:29097544).
In neurons, involved in the regulation of dendritic Ca2+ dynamics by regulating mitochondrial Ca2+ uptake in neurons (PubMed:29097544).
Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987).
May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Lipid transportIEA:UniProtKB-KW
Mitochondrial calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion-endoplasmic reticulum membrane tetheringManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Localizes at mitochondria-endoplasmic reticulum contact sites.
Topology
Helical: 2-24
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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