PDZD8

PDZD8 has broad expression in bone marrow (RPKM 51.5), testis (RPKM 17.7) and 24 other tissues.

Full Name

PDZ domain containing 8

Function

Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544).
PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca2+ transfer (PubMed:29097544).
In neurons, involved in the regulation of dendritic Ca2+ dynamics by regulating mitochondrial Ca2+ uptake in neurons (PubMed:29097544).
Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987).
May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Lipid transportIEA:UniProtKB-KW
Mitochondrial calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrion-endoplasmic reticulum membrane tetheringManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum membrane
Localizes at mitochondria-endoplasmic reticulum contact sites.

Topology

Helical: 2-24