Rabbit Anti-PEA15 Recombinant Antibody (D1G6A) (CBMAB-P1396-YC)

Name: Rabbit Anti-PEA15 Recombinant Antibody (D1G6A)
SKU: CBMAB-P1396-YC
Rating: 5 (1 reviews)

See all PEA15 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D1G6A

Application

WB, IP

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proliferation And Apoptosis Adaptor Protein 15

Introduction

PEA15 is a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Entrez Gene ID

Human	8682
Mouse	18611
Rat	364052

UniProt ID

Human	Q15121
Mouse	Q62048
Rat	Q5U318

Alternative Names

Proliferation And Apoptosis Adaptor Protein 15; Phosphoprotein Enriched In Diabetes; 15 KDa Phosphoprotein Enriched In Astrocytes; Phosphoprotein Enriched In Astrocytes 15; Proliferation And Apoptosis Adaptor 15; Homolog Of Mouse MAT-1 Oncogene; PED; Mammary Transforming Gene 1, Mouse, Homolog Of; Phosphoprotein Enriched In Astrocytes, 15kD;

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity).
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Carbohydrate transportIEA:UniProtKB-KW
MAPK cascadeIEA:InterPro
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Response to morphineIEA:Ensembl

Cellular Location

Cytoplasm
Associated with microtubules.

PTM

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-PEA15 Recombinant Antibody (D1G6A)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry