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Rabbit Anti-PEA15 Recombinant Antibody (D1G6A) (CBMAB-P1396-YC)

Provided herein is a Rabbit monoclonal antibody against Human Proliferation And Apoptosis Adaptor Protein 15. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PEA15 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D1G6A
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proliferation And Apoptosis Adaptor Protein 15
Introduction
PEA15 is a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
Entrez Gene ID
Human8682
Mouse18611
Rat364052
UniProt ID
HumanQ15121
MouseQ62048
RatQ5U318
Alternative Names
Proliferation And Apoptosis Adaptor Protein 15; Phosphoprotein Enriched In Diabetes; 15 KDa Phosphoprotein Enriched In Astrocytes; Phosphoprotein Enriched In Astrocytes 15; Proliferation And Apoptosis Adaptor 15; Homolog Of Mouse MAT-1 Oncogene; PED; Mammary Transforming Gene 1, Mouse, Homolog Of; Phosphoprotein Enriched In Astrocytes, 15kD;
Function
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity).
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Carbohydrate transportIEA:UniProtKB-KW
MAPK cascadeIEA:InterPro
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Response to morphineIEA:Ensembl
Cellular Location
Cytoplasm
Associated with microtubules.
PTM
Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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