PEA15

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Full Name

Proliferation And Apoptosis Adaptor Protein 15

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity).
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Carbohydrate transportIEA:UniProtKB-KW
MAPK cascadeIEA:InterPro
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Response to morphineIEA:Ensembl

Cellular Location

Cytoplasm
Associated with microtubules.

PTM

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.