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Mouse Anti-PEAK1 Recombinant Antibody (3E7) (CBMAB-K2191-LY)

This product is antibody recognizes PEAK1. The antibody 3E7 immunoassay techniques such as: IF, WB.
See all PEAK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E7
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
KIAA2002 (XP_370878, 1151 a.a. ~ 1250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Pseudopodium Enriched Atypical Kinase 1
Introduction
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Entrez Gene ID
79834
UniProt ID
Q9H792
Alternative Names
Pseudopodium Enriched Atypical Kinase 1; Tyrosine-Protein Kinase SgK269; Sugen Kinase 269; Pseudopodium-Enriched Atypical Kinase 1; NKF3 Kinase Family Member; EC 2.7.10.2; KIAA2002; SGK269;
Function
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451).
Acts as a scaffold for mediating EGFR signaling (PubMed:23846654).
Biological Process
Cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of focal adhesion assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Colocalizes with F-actin in serum-rich medium (PubMed:20534451).
Actin colocalization is reduced during serum starvation (PubMed:20534451).
PTM
Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451).
Phosphorylation at Tyr-665 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics (PubMed:20534451).
Phosphorylation at Tyr-1188 is essential for binding to SHC1 (PubMed:23846654).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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