PEAK1

This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]

Full Name

Pseudopodium Enriched Atypical Kinase 1

Function

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451).
Acts as a scaffold for mediating EGFR signaling (PubMed:23846654).

Biological Process

Cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of focal adhesion assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Colocalizes with F-actin in serum-rich medium (PubMed:20534451).
Actin colocalization is reduced during serum starvation (PubMed:20534451).

PTM

Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451).
Phosphorylation at Tyr-665 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics (PubMed:20534451).
Phosphorylation at Tyr-1188 is essential for binding to SHC1 (PubMed:23846654).