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Rabbit Anti-PFN1 Recombinant Antibody (CBYC-P313) (CBMAB-P1525-YC)

Provided herein is a Rabbit monoclonal antibody against Human Profilin 1. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all PFN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-P313
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Profilin 1
Introduction
PFN1 is a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.
Entrez Gene ID
5216
UniProt ID
P07737
Alternative Names
Profilin 1; Epididymis Tissue Protein Li 184a; Profilin I; Profilin-1; ALS18;
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Biological Process
Actin cytoskeleton organizationIEA:InterPro
Modification of postsynaptic actin cytoskeletonIEA:Ensembl
Negative regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Neural tube closureIEA:Ensembl
Positive regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of actin filament polymerizationManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of ATP-dependent activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of ruffle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIIEA:Ensembl
Synapse maturationIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Involvement in disease
Amyotrophic lateral sclerosis 18 (ALS18):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
PTM
Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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