Mouse Anti-PFN2 Recombinant Antibody (6G3) (CBMAB-P1528-YC)

Name: Mouse Anti-PFN2 Recombinant Antibody (6G3)
SKU: CBMAB-P1528-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6G3

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Profilin 2

Introduction

PFN2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Entrez Gene ID

5217

UniProt ID

P35080

Alternative Names

Profilin 2; Profilin II; Profilin-2; D3S1319E; PFL;

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Biological Process

Actin cytoskeleton organizationIEA:InterPro
Modification of postsynaptic actin cytoskeletonIEA:Ensembl
Negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ruffle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of actin filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of actin filament polymerizationManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of ATP-dependent activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic vesicle exocytosisIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PFN2 Recombinant Antibody (CBYC-P314) (CAT#: CBMAB-P1529-YC)

Mouse Anti-PFN2 Recombinant Antibody (CF335) (CAT#: CBMAB-FT163LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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